Progestin Receptor beta/mprb (AA 251-300) antibody

Catalog No. ABIN1387676

There is 1 publication for this product available. The Rabbit Polyclonal anti-Progestin Receptor beta/mprb antibody is suitable to detect Progestin Receptor beta/mprb in samples from Human. It has been validated for WB.

Quick Overview for Progestin Receptor beta/mprb (AA 251-300) antibody (ABIN1387676)

Target: Progestin Receptor beta/mprb

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Product Details

Binding Specificity: AA 251-300

Purpose: Progestin Receptor Beta Polyclonal Antibody

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Progestin Receptor Beta

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References

Kasubuchi, Watanabe, Hirano, Inoue, Li, Terasawa, Konishi, Itoh, Kimura: "Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling." in: Scientific reports, Vol. 7, Issue 1, pp. 5168, (2017) (PubMed).

Target Details

Target: Progestin Receptor beta/mprb

Background:

Synonyms: C6orf33, LMPB1, Lysosomal membrane protein in brain 1, Membrane progestin receptor beta, mPR beta, MPRB, PAQR8, Progestin and adipoQ receptor family member 8, Progestin and adipoQ receptor family member VIII, MPRB_HUMAN.

Background: The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways. Five distinct groups, designated Alpha, Beta, Gamma, Delta, comprise the mPR gene family. mPR Alpha, also designated progestin and adipo Theta receptor family member VII (PAQR7), consists of an extracellular N-terminus, an intracellular C-terminus and seven transmembrane domains. mPR Alpha is expressed in ovary, testis, placenta, uterus and bladder. mPR Beta, or progestin and adipo Theta receptor family member VIII (PAQR8), consists of eight putative transmembrane regions and an intracellular N-terminus that contains a leucine-rich motif. mPR Beta is a 354 amino acid protein expressed in brain and spinal cord. Both mPR Alpha and mPR Beta may be G protein-coupled receptors and may be involved in oocyte maturation.

Gene ID: 85315