TFAM antibody (AA 155-246)

Catalog No. ABIN1387734

This anti-TFAM antibody is a Rabbit Polyclonal antibody detecting TFAM in WB, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). Suitable for Mouse and Rat. This Primary Antibody has been cited in 3+ publications.

Quick Overview for TFAM antibody (AA 155-246) (ABIN1387734)

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFAM antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TFAM Antibody

Binding Specificity: AA 155-246

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Rabbit,Goat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MtTF1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-TFAM antibody (ABIN1387734)

Yan, Liu, Guan, Guo: "Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice." in: Endocrine connections, Vol. 7, Issue 4, pp. 604-616, (2018) (PubMed).

You, Hou, Zhai, Li, Li, Zhao, Zhao: "Protective effects of PGC-1α via the mitochondrial pathway in rat brains after intracerebral hemorrhage." in: Brain research, Vol. 1646, pp. 34-43, (2016) (PubMed).

Yan, Ji, Shi, Li, Sang: "Acute nitrogen dioxide inhalation induces mitochondrial dysfunction in rat brain." in: Environmental research, Vol. 138, pp. 416-24, (2015) (PubMed).

Target Details for TFAM

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Alternative Name: MtTF1

Background:

Synonyms: TCF6, MTTF1, MTTFA, TCF6L1, TCF6L2, TCF6L3, Transcription factor A, mitochondrial, Mitochondrial transcription factor 1, Transcription factor 6, TCF-6, Transcription factor 6-like 2, TFAM

Background: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.

Gene ID: 7019

UniProt: Q00059

Pathways: Chromatin Binding