HSP70 1A/ 1B (AA 500-600) antibody

Catalog No. ABIN1387822

This Rabbit Polyclonal antibody specifically detects HSP70 1A/ 1B in WB, FACS, IHC (p) and ELISA. It exhibits reactivity toward Human, Chicken, Mouse, Pig and Rat. It has been mentioned in 2+ publications

Quick Overview for HSP70 1A/ 1B (AA 500-600) antibody (ABIN1387822)

Target: HSP70 1A/ 1B

Reactivity: Human, Chicken, Mouse, Pig, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA

Product Details

Binding Specificity: AA 500-600

Cross-Reactivity: Chicken, Human, Mouse, Pig, Rat

Predicted Reactivity: Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HSP70 1A/1B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References

Oyagbemi, Omobowale, Ola-Davies, Asenuga, Ajibade, Adejumobi, Arojojoye, Afolabi, Ogunpolu, Falayi, Hassan, Ochigbo, Saba, Adedapo, Yakubu: "Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARγ signaling pathways." in: BioFactors (Oxford, England), Vol. 44, Issue 5, pp. 465-479, (2019) (PubMed).

Zheng, Liu, Li, Tang, Zhang, Tang: "Lithium posttreatment confers neuroprotection through glycogen synthase kinase-3β inhibition in intracerebral hemorrhage rats." in: Journal of neurosurgery, pp. 1-9, (2016) (PubMed).

Target Details

Target: HSP70 1A/ 1B

Alternative Name: HSP70 1A/1B

Background:

Synonyms: HSP72, HSPA1, HSP70I, HSP70-1, HSP70-1A, HEL-S-103, Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP70.1/HSP70.2, HSPA1A, HSX70

Background: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

Gene ID: 3303

UniProt: P08107