SORCS1 antibody (AA 561-660) (AbBy Fluor® 647)

Catalog No. ABIN1390632

The AbBy Fluor® 647-conjugated Rabbit Polyclonal anti-SORCS1 antibody (ABIN1390632) specifically detects SORCS1 in IF (cc) and IF (p). The antibody is reactive with Human samples.

Quick Overview for SORCS1 antibody (AA 561-660) (AbBy Fluor® 647) (ABIN1390632)

Target: SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SORCS1 antibody is conjugated to AbBy Fluor® 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-SORCS1 Antibody (AbBy Fluor® 647)

Binding Specificity: AA 561-660

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SORCS1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SORCS1

Target: SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))

Alternative Name: SORCS1

Background:

Synonyms: SorCS 1, SORCS, SORCS-1, SORCS receptor 1, Sortilin related VPS10 domain containing receptor 1, VPS10 domain containing receptor SorCS1, VPS10 domain receptor protein SORCS 1, VPS10 domain receptor protein SORCS, VPS10 domain receptor protein SORCS1, VPS10 domain receptor SorCS, FLJ41758, FLJ43475, FLJ44957, hSorCS, OTTHUMP00000058855, SORC1_HUMAN.

Background: There are three sorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, the homologous SorCS1 and SorCS2 genes and the SorCS3 gene are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS1 is a type 1 receptor containing a VPS10P domain and a leucine-rich domain. Alternative splicing of human SorCS1 results in four isoforms with different cytoplasmic tails and differential expression in tissues. Human SorCS1 is detected in fetal and infant brain and in fetal retina. Alternative splicing of murine SorCS1 also results in four isoforms. Murine isoform 1 is highly expressed in brain and at lower levels in heart, liver and kidney. It is detected in newborn mouse brain and in adult olfactory bulb and cerebral cortex. Murine isoform 2 is highly expressed in liver and at lower levels in heart, brain, kidney and testis.