CPT1C antibody (AA 121-170) (Biotin)

Catalog No. ABIN1391149

This Rabbit Polyclonal antibody specifically detects CPT1C in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for CPT1C antibody (AA 121-170) (Biotin) (ABIN1391149)

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPT1C antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CPT1C Antibody (Biotin)

Binding Specificity: AA 121-170

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Cpt1c

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CPT1C

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Alternative Name: Cpt1c

Background:

Synonyms: CPT1-C, Carnitine acyltransferase like protein 1, Carnitine acyltransferase like protein1, Carnitine O palmitoyltransferase I, brain isoform, Carnitine palmitoyltransferase 1, brain, Carnitine palmitoyltransferase 1C, Carnitine palmitoyltransferase I related C, Carnitine palmitoyltransferase1C, CAT L1, CATL 1, CATL1, CPT 1 like pseudogene, Cpt 1c, CPT 1P, CPT I C, Cpt1 c, CPT1 like pseudogene, CPT1P , CPTIC.CPT1C_HUMAN

Background: The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.

Gene ID: 126129

Pathways: AMPK Signaling, Monocarboxylic Acid Catabolic Process