CPT1C antibody (AA 752-782)

Catalog No. ABIN3030283

Product Details anti-CPT1C Antibody

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Binding Specificity: AA 752-782

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPT1C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 752-782 from the human protein was used as the immunogen for this CPT1C antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the CPT1C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CPT1C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for CPT1C

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Alternative Name: CPT1C (CPT1C Products)

Synonyms: 6530437J22Rik antibody, 9630004I06Rik antibody, CATL1 antibody, CPT1-B antibody, CPT1P antibody, CPTI-B antibody, CPTIC antibody, CPT IC antibody, carnitine palmitoyltransferase 1c antibody, carnitine palmitoyltransferase 1C antibody, Cpt1c antibody, CPT1C antibody

Background: The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.

UniProt: Q8TCG5

Pathways: AMPK Signaling, Monocarboxylic Acid Catabolic Process