Semaphorin 6C antibody (AA 256-305) (AbBy Fluor® 350)

Catalog No. ABIN1391535

The AbBy Fluor® 350-conjugated Rabbit Polyclonal anti-Semaphorin 6C antibody (ABIN1391535) specifically detects Semaphorin 6C in WB, IF (cc) and IF (p). The antibody is reactive with Human samples.

Quick Overview for Semaphorin 6C antibody (AA 256-305) (AbBy Fluor® 350) (ABIN1391535)

Target: Semaphorin 6C (SEMA6C) (Sema Domain, Transmembrane Domain (TM), and Cytoplasmic Domain, (Semaphorin) 6C (SEMA6C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Semaphorin 6C antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Semaphorin 6C Antibody (AbBy Fluor® 350)

Binding Specificity: AA 256-305

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SEMA6C

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Semaphorin 6C

Target: Semaphorin 6C (SEMA6C) (Sema Domain, Transmembrane Domain (TM), and Cytoplasmic Domain, (Semaphorin) 6C (SEMA6C))

Alternative Name: SEMA6C

Background:

Synonyms: KIAA1869, m Sema Y, m Sema Y2, sema domain, transmembrane domain TM, and cytoplasmic domain, semaphorin 6C, Sema Y antibody Semaphorin 6C [Precursor], Semaphorin Y, SEMAY, SEM6C_HUMAN.

Background: Semaphorins are a family of cell surface and secreted proteins involved in neural development that are conserved from insects to humans. Members of this family are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular semaphorin? domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. The transmembrane semaphorins are characterized by an additional 80 amino acid transmembrane domain and an 80-110 amino acid cytoplasmic domain. SEMA6C, also known as SEMA Y, is a transmembrane protein expressed in fetal brain and adult skeletal muscle. Three isoforms of this semaphorin exist due to alternative splicing: SEMA6C 1, SEMA6C 2 and SEMA6C 3. The extracellular domain of SEMA6C induces growth cone collapse of dorsal root ganglion and plays a role in generation or stability of entorhino-hippocampal synapses.