PDE7A antibody (AbBy Fluor® 488)

Catalog No. ABIN1392082

This Rabbit Polyclonal antibody specifically detects PDE7A in WB, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for PDE7A antibody (AbBy Fluor® 488) (ABIN1392082)

Target: PDE7A (phosphodiesterase 7A (PDE7A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE7A antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-PDE7A Antibody (AbBy Fluor® 488)

Purpose: PDE7A Polyclonal Antibody, AbBy Fluor-488 Conjugated

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PDE7A

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000), IF(1:100-500), Flow-Cyt(1 μg/Test)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PDE7A

Target: PDE7A (phosphodiesterase 7A (PDE7A))

Alternative Name: Pde7a

Background:

Synonyms: HCP 1, HCP1, High affinity cAMP specific 3'5' cyclic phosphodiesterase 7A, High affinity cAMP-specific 3'', P2A, PDE 7, PDE 7A, PDE7, PDE71, PDE7A, PDE7A_HUMAN, Phosphodiesterase 7A, Phosphodiesterase isozyme 7, Phosphodiesterase7A, Rolipram insensitive phosphodiesterase type 7, TM 22, TM22, 5''-cyclic phosphodiesterase 7A.

Background: Phosphodiesterases (PDE, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP. Phosphodiesterase type 3 isoforms, PDE3A and 3B, are expressed primarily in cardiovascular tissue and adipose tissue, respectively. PDE3A, is found in myocardium and platelets and PDE3B is found in lymphocytes. The PDE7A1 (HCP1) isozyme and the PDE7A2 proteins, alternate splice products of PDE7A, are highly expressed in skeletal muscle. PDE7B is most highly expressed in pancreas. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation.

Gene ID: 5150

UniProt: Q13946

Pathways: cAMP Metabolic Process