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GBX2 antibody (AA 251-348) (Biotin)

GBX2 Reactivity: Rat WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1393687
  • Target See all GBX2 Antibodies
    GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))
    Binding Specificity
    • 15
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-348
    Reactivity
    • 24
    • 19
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Rat
    Host
    • 28
    • 10
    • 1
    Rabbit
    Clonality
    • 29
    • 10
    Polyclonal
    Conjugate
    • 21
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GBX2 antibody is conjugated to Biotin
    Application
    • 31
    • 16
    • 14
    • 13
    • 13
    • 6
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Rat
    Predicted Reactivity
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Gbx2
    Isotype
    IgG
    Top Product
    Discover our top product GBX2 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))
    Alternative Name
    Gbx2 (GBX2 Products)
    Synonyms
    gbx-2 antibody, fd07f12 antibody, wu:fd07f12 antibody, GBX2 antibody, D130058E05Rik antibody, Gbx-2 antibody, MMoxA antibody, Stra7 antibody, gbx2 antibody, gastrulation brain homeobox 2 antibody, gastrulation brain homeobox 2, gene 2 L homeolog antibody, gbx2 antibody, GBX2 antibody, Gbx2 antibody, gbx2.2.L antibody
    Background

    Synonyms: Gastrulation and brain-specic homeobox protein 2, Gastrulation brain homeo box 2 , Gastrulation brain homeo box 2, gbx2, GBX2_HUMAN, Homeobox protein GBX 2 , Homeobox protein GBX 2, Homeobox protein GBX-2, Homeobox protein STRA7, Mmoxa.

    Background: The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes Gbx2 and Otx2. Gbx2 and Otx2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, Gbx2 negatively regulates Otx2 expression along the anterior-posterior axis, Gbx2(-) mutants demonstrate an expanded Otx2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. Gbx2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is over-expressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of Gbx2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that Gbx2 expression may be required for growth of malignant prostate cells.

    Pathways
    Dopaminergic Neurogenesis
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