Metabotropic Glutamate Receptor 1 antibody (AA 151-250) (Biotin)

Catalog No. ABIN1394641

This Rabbit Polyclonal antibody specifically detects Metabotropic Glutamate Receptor 1 in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Mouse and Zebrafish (Danio rerio).

Quick Overview for Metabotropic Glutamate Receptor 1 antibody (AA 151-250) (Biotin) (ABIN1394641)

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reactivity: Mouse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Metabotropic Glutamate Receptor 1 Antibody (Biotin)

Binding Specificity: AA 151-250

Cross-Reactivity: Mouse, Zebrafish (Danio rerio)

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MGLUR1A/Metabotropic Glutamate Receptor 1a

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Alternative Name: MGLUR1A/Metabotropic Glutamate Receptor 1a

Background:

Synonyms: G protein coupled receptor family C group 1 member A, Glutamate receptor metabotropic 1 alpha, Glutamate receptor metabotropic 1, GPRC1A, GRM 1, GRM1 alpha, GRM1, GRM1A, Human metabotropic glutamate receptor 1 alpha mRNA complete cds, Metabotropic glutamate receptor 1 alpha, Metabotropic glutamate receptor 1, mGlu1, MGLUR1, MGLUR1A, mGluR1alpha.

Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined.