GDE1 antibody (AA 231-331) (Biotin)

Catalog No. ABIN1394809

This Rabbit Polyclonal antibody specifically detects GDE1 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Mouse.

Quick Overview for GDE1 antibody (AA 231-331) (Biotin) (ABIN1394809)

Target: GDE1 (Glycerophosphodiester Phosphodiesterase 1 (GDE1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDE1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GDE1 Antibody (Biotin)

Binding Specificity: AA 231-331

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MIR16/GDE1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GDE1

Target: GDE1 (Glycerophosphodiester Phosphodiesterase 1 (GDE1))

Alternative Name: MIR16/GDE1

Background:

Synonyms: EC 3.1.4.44, GDE1, Glycerophosphodiester phosphodiesterase 1, Membrane interacting protein of RGS16, RGS16 interacting membrane protein, GDE1_HUMAN.

Background: GDE1 is a 331 amino acid multi-pass membrane protein that localizes to both the membrane and the cytoplasm and contains one GDPD domain. Expressed in a wide variety of tissues, GDE1 uses magnesium as a cofactor to catalyze the conversion of 1-(sn-glycero-3-phospho)-1D-myo-inositol to myo-inositol and sn-glycerol 3-phosphate, an event that is modulated by G protein signaling pathways and provides a link between phosphoinositide metabolism and G protein signal transduction. The gene encoding GDE1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3 % of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.