SCN2B antibody (AA 65-180) (Biotin)

Catalog No. ABIN1395289

This Rabbit Polyclonal antibody specifically detects SCN2B in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for SCN2B antibody (AA 65-180) (Biotin) (ABIN1395289)

Target: SCN2B (Sodium Channel, Voltage-Gated, Type II, beta (SCN2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN2B antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SCN2B Antibody (Biotin)

Binding Specificity: AA 65-180

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SCN2B

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SCN2B

Target: SCN2B (Sodium Channel, Voltage-Gated, Type II, beta (SCN2B))

Alternative Name: SCN2B

Background:

Synonyms: Neuronal voltage gated sodium channel beta 2 subunit, Scn 2b, Scn2b, SCN2B_HUMAN, Sodium channel beta 2 subunit, Sodium channel subunit beta 2, Sodium channel subunit beta-2, Sodium channel voltage gated type II beta, Sodium channel voltage gated type II beta polypeptide.

Background: Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type II beta(sodium channel, voltage-gated, type II, beta), also known as SCN2B, is a 215 amino acid single-pass type I membrane protein that plays a critical role in the expression and assembly of the heterotrimeric complex of the sodium channel and interacts with Tenascin-R to influence the clustering and regulation of sodium channels at nodes of Ranvier. Expressed specifically in brain, Na+ CP type II beta contains one Ig-like C2-type (immunoglobulin-like) domain and is encoded by a gene that maps to human chromosome 11q23.3 and mouse chromosome 9 A5.2.