ZNF281 antibody (AbBy Fluor® 555)

Catalog No. ABIN1395791

The Rabbit Polyclonal anti-ZNF281 antibody has been validated for WB. It is suitable to detect ZNF281 in samples from Human, Mouse and Rat.

Quick Overview for ZNF281 antibody (AbBy Fluor® 555) (ABIN1395791)

Target: ZNF281 (Zinc Finger Protein 281 (ZNF281))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF281 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB)

Product Details anti-ZNF281 Antibody (AbBy Fluor® 555)

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZNF281

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ZNF281

Target: ZNF281 (Zinc Finger Protein 281 (ZNF281))

Alternative Name: Znf281

Background:

Synonyms: Zfp281, GC box binding zinc finger protein 1, GC-box-binding zinc finger protein 1, GZP1, Transcription factor ZBP-99, ZBP 99, ZBP99, zfp281, Zinc finger DNA binding protein 99, Zinc finger DNA-binding protein 99, Zinc Finger Protein 281, ZN281_HUMAN, ZNF281, ZNP 99, ZNP 99 transcription factor, ZNP99.

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF281, also known as GC-box-binding zinc finger protein 1, ZBP-99 or ZNP-99 (zinc finger DNA-binding protein 99), is a zinc finger protein that belongs to the Kr_ppel C2H2-type zinc finger protein family. It is expressed ubiquitously at low levels with predominant expression in kidney, liver, lymphocytes and placenta. ZNF281 localizes to the nucleus and contains four C2H2-type zinc fingers. ZNF281 plays a role in repressing the transcription of a variety of genes including Gastrin and ODC (ornithine decarboxylase). In particular, ZNF281 functions by binding to the G-rich box in the enhancer region of the gene. Upon DNA damage, ZNF281 may become phosphorylated by Atm or ATR.

Gene ID: 23528

Pathways: Embryonic Body Morphogenesis