Complement Factor B antibody (AA 301-400) (AbBy Fluor® 488)

Catalog No. ABIN1397647

This Rabbit Polyclonal antibody specifically detects Complement Factor B in WB and IF (p). It exhibits reactivity toward Mouse and Rat.

Quick Overview for Complement Factor B antibody (AA 301-400) (AbBy Fluor® 488) (ABIN1397647)

Target: Complement Factor B (CFB)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor B antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Complement Factor B Antibody (AbBy Fluor® 488)

Binding Specificity: AA 301-400

Cross-Reactivity: Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Complement factor-B Bb fragment

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Complement Factor B

Target: Complement Factor B (CFB)

Alternative Name: Factor B

Background:

Synonyms: BF, FB, BFD, GBG, CFAB, CFBD, PBF2, AHUS4, FBI12, H2-Bf, ARMD14, Complement factor B, C3/C5 convertase, Glycine-rich beta glycoprotein, Properdin factor B, CFB

Background: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Gene ID: 629

UniProt: P00751

Pathways: Complement System, Proton Transport, Ribonucleoside Biosynthetic Process