TAS2R38 antibody (AA 151-250) (AbBy Fluor® 488)

Catalog No. ABIN1400056

This Rabbit Polyclonal antibody specifically detects TAS2R38 in IF (p) and IF (cc). It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for TAS2R38 antibody (AA 151-250) (AbBy Fluor® 488) (ABIN1400056)

Target: TAS2R38 (Taste Receptor, Type 2, Member 38 (TAS2R38))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAS2R38 antibody is conjugated to AbBy Fluor® 488

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-TAS2R38 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 151-250

Cross-Reactivity: Human

Predicted Reactivity: Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human T2R38/TAS2R38

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-TAS2R38 antibody (AbBy Fluor® 488) (ABIN1400056)

Gaida, Dapunt, Hänsch: "Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells." in: Pathogens and disease, Vol. 74, Issue 3, (2016) (PubMed).

Maurer, Wabnitz, Kahle, Stegmaier, Prior, Giese, Gaida, Samstag, Hänsch: "Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone." in: Frontiers in immunology, Vol. 6, pp. 369, (2015) (PubMed).

Target Details for TAS2R38

Target: TAS2R38 (Taste Receptor, Type 2, Member 38 (TAS2R38))

Alternative Name: T2R38

Background:

Synonyms: PTC, PTC bitter taste receptor, T2R38, T2R61, taste receptor, type 2, member 38, T2R38_HUMAN.

Background: The sense of taste is essential for the survival of organisms. For example, the ability to identify sweet-tasting foods enables animals to seek out food with high nutritive value, whereas the ability to identify bitter substances enables them to avoid the ingestion of potentially harmful substances. A family of integral membrane proteins are involved in taste perception and include T1R, which is involved in sweet taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. Specifically, T2R38 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in T2R38 are associated with the ability to taste the bitter chemical phenylthiocarbamide (PTC), also called thiourea tasting.

Gene ID: 5726