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VGLL4 antibody (AA 220-270) (AbBy Fluor® 555)

The Rabbit Polyclonal anti-VGLL4 antibody has been validated for WB and IF (p). It is suitable to detect VGLL4 in samples from Human, Mouse and Rat.
Catalog No. ABIN1401329

Quick Overview for VGLL4 antibody (AA 220-270) (AbBy Fluor® 555) (ABIN1401329)

Target

See all VGLL4 Antibodies
VGLL4 (Vestigial Like 4 (VGLL4))

Reactivity

  • 32
  • 15
  • 15
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Mouse, Rat

Host

  • 31
  • 1
Rabbit

Clonality

  • 32
Polyclonal

Conjugate

  • 10
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This VGLL4 antibody is conjugated to AbBy Fluor® 555

Application

  • 26
  • 12
  • 12
  • 3
  • 2
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Binding Specificity

    • 14
    • 7
    • 6
    • 1
    • 1
    • 1
    • 1
    AA 220-270

    Cross-Reactivity

    Human, Mouse, Rat

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human VGLL4

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    VGLL4 (Vestigial Like 4 (VGLL4))

    Alternative Name

    VGLL4

    Background

    Synonyms: Transcription cofactor vestigial like protein 4, Vestigial like protein 4, VGL 4, VGLL4, VGLL4_HUMAN.

    Background: The transcriptional enhancer factor-1 (TEF-1) family of transcription factors regulate tissue-specific gene expression in muscle and placenta. The mechanism whereby TEF-1 confers tissue specificity depends largely on the interaction of TEF-1 with tissue-specific cofactors. Transcription cofactor Vgl-4 (vestigial-like protein 4) is a 290 amino acid nuclear protein that interacts with TEF-1 and MEF-2. Vgl-4 is the only member of the vestigial-like family that is expressed in heart. Overexpression of Vgl-4 in cardiac myocytes interferes with basal expression and ?-adrenergic receptor-dependent activation of a TEF-1 dependent skeletal ?actin promoter. This suggests that Vgl-4 counteracts ?-adrenergic activation of gene expression in cardiomyocytes. There are two isoforms of Vgl-4 that are produced as a result of alternative splicing events.

    Gene ID

    9686

    UniProt

    Q14135
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