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PDZRN3 antibody (Biotin)

PDZRN3 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1401367
  • Target See all PDZRN3 Antibodies
    PDZRN3 (PDZ Domain Containing Ring Finger 3 (PDZRN3))
    Reactivity
    • 25
    • 18
    • 16
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 24
    • 1
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PDZRN3 antibody is conjugated to Biotin
    Application
    • 21
    • 13
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SEMCAP3/LNX3
    Isotype
    IgG
    Top Product
    Discover our top product PDZRN3 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    PDZRN3 (PDZ Domain Containing Ring Finger 3 (PDZRN3))
    Alternative Name
    SEMCAP3 (PDZRN3 Products)
    Synonyms
    MGC80196 antibody, pdzrn3 antibody, LNX3 antibody, SEMACAP3 antibody, 1110020C07Rik antibody, AI429718 antibody, AL023082 antibody, Semcap3 antibody, PDZ domain containing ring finger 3 antibody, PDZ domain containing ring finger 3 L homeolog antibody, PDZ domain containing RING finger 3b antibody, E3 ubiquitin-protein ligase PDZRN3 antibody, PDZ domain containing RING finger 3 antibody, PDZRN3 antibody, pdzrn3.L antibody, pdzrn3b antibody, LOC100228989 antibody, pdzrn3 antibody, Pdzrn3 antibody
    Background

    Synonyms: Ligand of Numb protein X 3, likely ortholog of mouse semaF cytoplasmic domain associated protein 3, LNX3, PDZ domain containing ring finger 3, Protein SEMACAP3, SEMACAP3, Semaphorin cytoplasmic domain associated protein, PZRN3_HUMAN.

    Background: PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.

    Gene ID
    23024
    Pathways
    Skeletal Muscle Fiber Development
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