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RNF31 antibody (Biotin)

RNF31 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1401667
  • Target See all RNF31 Antibodies
    RNF31 (Ring Finger Protein 31 (RNF31))
    Reactivity
    • 46
    • 21
    • 18
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 45
    • 1
    Rabbit
    Clonality
    • 46
    Polyclonal
    Conjugate
    • 19
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RNF31 antibody is conjugated to Biotin
    Application
    • 40
    • 20
    • 13
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human RNF31
    Isotype
    IgG
    Top Product
    Discover our top product RNF31 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    RNF31 (Ring Finger Protein 31 (RNF31))
    Alternative Name
    RNF31 (RNF31 Products)
    Synonyms
    RNF31 antibody, HOIP antibody, ZIBRA antibody, AL033293 antibody, BC031509 antibody, Flj10111 antibody, Paul antibody, mFLJ00217 antibody, ring finger protein 31 antibody, RNF31 antibody, rnf31 antibody, Rnf31 antibody
    Background

    Synonyms: HOIP, ZIBRA, E3 ubiquitin-protein ligase RNF31, HOIL-1-interacting protein, RING finger protein 31, Zinc in-between-RING-finger ubiquitin-associated domain protein, RNF31

    Background: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

    Gene ID
    55072
    UniProt
    Q96EP0
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