CAF1p55 antibody (FITC)

Catalog No. ABIN1402454

The Rabbit Polyclonal anti-CAF1p55 antibody is suitable to detect CAF1p55 in samples from Human. It has been validated for IF and FACS.

Quick Overview for CAF1p55 antibody (FITC) (ABIN1402454)

Target: CAF1p55 (CAF1) (Chromatin Assembly Factor 1 Subunit (CAF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAF1p55 antibody is conjugated to FITC

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-CAF1p55 Antibody (FITC)

Purpose: CAF1p55/VPRBP Polyclonal Antibody, FITC Conjugated

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CAF1p55

Isotype: IgG

Application Details

Application Notes: IF(), Flow-Cyt(1 μg/Test)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CAF1p55

Target: CAF1p55 (CAF1) (Chromatin Assembly Factor 1 Subunit (CAF1))

Alternative Name: CAF1p55

Background:

Synonyms: Caf 1, CAF-1, CAF-1 P55 subunit, CAF1 p55 subunit, CAF1A, CAF1P55, chaf1b, Chromatin assembly factor 1 p55 subunit, Chromatin assembly factor 1 p60 subunit, chromatin assembly factor 1 subunit, Chromatin assembly factor I, dCAF-1, dCAF1, Human chromatin assembly factor-I p55 subunit, Nucleosome remodeling factor 55 kDa subunit, NURF 55, NURF-55, p55, Probable histone binding protein Caf1, VPRBP_HUMAN.

Background: P55 is an extensively palmitoylated erythrocyte membrane protein, and a member of the MAGUK family. P55 also resists salt extraction, resulting in a high affinity for the plasma membrane. P55 contains a PDZ/DHR domain, a conserved SH-3 domain that appears to suppress tyrosine kinase activity of various oncoproteins, a 39-amino acid motif that binds to cytoskeletal protein 4.1R, and a guanylate kinase-like domain. Interaction with glycophorin C (GPC) and 4.1R suggests that p55 may play a role in the dynamic regulation in the erythrocyte membrane. In addition, p55 gene expression in vivo may be associated with a CpG island. P55 is constitutively expressed in K562 erythroleukemia cells during erythropoiesis and undergoes a 2-fold amplification after induction.

Gene ID: 9730