BMP10 antibody (AA 350-400) (Biotin)

Catalog No. ABIN1402765

This Rabbit Polyclonal antibody specifically detects BMP10 in WB, IHC (p). It exhibits reactivity toward Human, Mouse, Rat.

Quick Overview for BMP10 antibody (AA 350-400) (Biotin) (ABIN1402765)

Target: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP10 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BMP10 Antibody (Biotin)

Binding Specificity: AA 350-400

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BMP10

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for BMP10

Target: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Alternative Name: BMP10

Background:

Synonyms: Bone morphogenetic protein 1, BMP-1, BMP1

Background: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Gene ID: 27302

UniProt: O95393

Pathways: Hormone Activity, Regulation of Muscle Cell Differentiation