INIP antibody (AA 1-50) (AbBy Fluor® 555)

Catalog No. ABIN1403027

The Rabbit Polyclonal anti-INIP antibody has been validated for WB and IF (p). It is suitable to detect INIP in samples from Human, Mouse and Rat.

Quick Overview for INIP antibody (AA 1-50) (AbBy Fluor® 555) (ABIN1403027)

Target: INIP (INTS3 and NABP Interacting Protein (INIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INIP antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-INIP Antibody (AbBy Fluor® 555)

Binding Specificity: AA 1-50

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SOSSC/C9orf80

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for INIP

Target: INIP (INTS3 and NABP Interacting Protein (INIP))

Alternative Name: SOSSC

Background:

Synonyms: INIP, Chromosome 9 open reading frame 80, hSSBIP1, MISE, RP11-276E15.2, Sensor of single-strand DNA complex subunit C, Sensor of ssDNA subunit C, Single-stranded DNA-binding protein-interacting protein 1, SOSS C, SOSS complex subunit C, SOSS-C, SOSSC, SOSSC_HUMAN, SSB-interacting protein 1, Ssbip1, C9orf80, INTS3- and NABP-interacting protein

Background: The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent signaling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.

Gene ID: 58493

UniProt: Q9NRY2