FECH antibody (AbBy Fluor® 555)

Catalog No. ABIN1403207

The Rabbit Polyclonal anti-FECH antibody has been validated for WB and IF (p). It is suitable to detect FECH in samples from Human, Mouse and Rat.

Quick Overview for FECH antibody (AbBy Fluor® 555) (ABIN1403207)

Target: FECH (Ferrochelatase (FECH))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FECH antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-FECH Antibody (AbBy Fluor® 555)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EPB41

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FECH

Target: FECH (Ferrochelatase (FECH))

Alternative Name: FECH

Background:

Synonyms: EPP, FCE, Ferrochelatase protoporphyria, Ferrochelatase, Ferrochelatase mitochondrial, Heme synthetase, Protoheme ferro lyase, HEMH_HUMAN.

Background: Ferrochelatase catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway, and is localised in the mitochondrion. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway (also called porphyrin pathway). They are broadly classified as hepatic porphyrias or erythropoietic porphyrias, based on the site of the overproduction and mainly accumulation of the porphyrins (or their chemical precursors). They manifest with either skin problems, or neurological complications, or occasionally both.

Gene ID: 2235

Pathways: Transition Metal Ion Homeostasis