FECH antibody (N-Term)

Catalog No. ABIN2777033

The Rabbit Polyclonal anti-FECH antibody is suitable to detect FECH in samples from Human and Rat. It has been validated for WB and IHC.

Quick Overview for FECH antibody (N-Term) (ABIN2777033)

Target: FECH (Ferrochelatase (FECH))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FECH antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FECH Antibody

Binding Specificity: N-Term

Purpose: FECH Antibody - N-terminal region

Sequence: QHAQGAKPQV QPQKRYESNI RKPKTGILML NMGGPETLGD VHDFLLRLFL

Predicted Reactivity: Human: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against FECH. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FECH

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8100603

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for FECH

Target: FECH (Ferrochelatase (FECH))

Alternative Name: FECH

Background:

Background Information: Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: Ferrochelatase

Alternative Symbols: EPP, FCE, EPP1

Protein Name: Ferrochelatase, mitochondrial

Molecular Weight: 48 kDa

Gene ID: 2235

NCBI Accession: NP_001012533

UniProt: Q8NAN0

Pathways: Transition Metal Ion Homeostasis