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Bestrophin 2 antibody (AA 101-200) (Cy5)

BEST2 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal Cy5
Catalog No. ABIN1406812
  • Target See all Bestrophin 2 (BEST2) Antibodies
    Bestrophin 2 (BEST2)
    Binding Specificity
    • 14
    • 8
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    AA 101-200
    Reactivity
    • 36
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 37
    Rabbit
    Clonality
    • 37
    Polyclonal
    Conjugate
    • 12
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Bestrophin 2 antibody is conjugated to Cy5
    Application
    • 21
    • 19
    • 18
    • 12
    • 12
    • 8
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Bestrophin 2
    Isotype
    IgG
    Top Product
    Discover our top product BEST2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Bestrophin 2 (BEST2)
    Alternative Name
    Bestrophin 2 (BEST2 Products)
    Synonyms
    VMD2L1 antibody, CG10173 antibody, Dmel\\CG10173 antibody, dbest2 antibody, Vmd2l1 antibody, best2 antibody, vmd2l1 antibody, MGC53680 antibody, MGC132361 antibody, Best2 antibody, GB16861 antibody, si:dkey-121b10.4 antibody, MGC75942 antibody, best2-a antibody, best2-b antibody, variant 2 antibody, bestrophin 2 antibody, Bestrophin 2 antibody, bestrophin 2 L homeolog antibody, uncharacterized LOC408898 antibody, bestrophin 2 S homeolog antibody, BEST2 antibody, Best2 antibody, best2.L antibody, LOC408898 antibody, best2 antibody, best2.S antibody
    Background

    Synonyms: BEST 2, Best disease Bestrophin, BEST2, Bestrophin2, FLJ20132, Vitellorm macular dystrophy 2 homolog, Vitellorm macular dystrophy 2 like 1, Vitellorm macular dystrophy 2 like protein 1, Vitellorm macular dystrophy, VMD2, VMD2 like gene 1, VMD2L1, BEST2_HUMAN.

    Background: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.

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