Bestrophin 4 antibody (AA 151-250) (HRP)

Catalog No. ABIN1406828

The Rabbit Polyclonal anti-Bestrophin 4 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect Bestrophin 4 in samples from Human.

Quick Overview for Bestrophin 4 antibody (AA 151-250) (HRP) (ABIN1406828)

Target: Bestrophin 4 (BEST4)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bestrophin 4 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Bestrophin 4 Antibody (HRP)

Binding Specificity: AA 151-250

Cross-Reactivity: Human

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Bestrophin 4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Bestrophin 4

Target: Bestrophin 4 (BEST4)

Alternative Name: Bestrophin 4

Background:

Synonyms: BEST 4, BEST4, BEST-4, Bestrophin 4, Bestrophin4, Bestrophin-4, Vitellorm macular dystrophy 2 like 2, Vitellorm macular dystrophy 2 like protein 2, VMD2L2, BEST4_HUMAN.

Background: Bestrophin-4 is a 473 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. Bestrophin-4 acts as a calcium-sensitive chloride channel located in the cell membrane. It is believed that Bestrophin-4 also acts as a channel for other physiologically significant anions, such as bicarbonate. Bestrophin-4 is predominantly expressed in the colon, but can be found at low levels in testis, placenta, trachea, spinal chord, lung and retina.