RAB17 antibody (AA 101-200) (Cy7)

Catalog No. ABIN1408014

This anti-RAB17 antibody is a Rabbit Polyclonal antibody detecting RAB17 in WB, IF (cc) and IF (p). Suitable for Human.

Quick Overview for RAB17 antibody (AA 101-200) (Cy7) (ABIN1408014)

Target: RAB17 (RAB17, Member RAS Oncogene Family (RAB17))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB17 antibody is conjugated to Cy7

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-RAB17 Antibody (Cy7)

Binding Specificity: AA 101-200

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Rab17

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RAB17

Target: RAB17 (RAB17, Member RAS Oncogene Family (RAB17))

Alternative Name: Rab17

Background:

Synonyms: Rab 17, Rab17, RAB17 member RAS oncogene family, RAB17_HUMAN, Ras related protein Rab 17, Ras related protein Rab17, Ras-related protein Rab-17, FLJ12538, OTTHUMP00000164417, OTTHUMP00000202805.

Background: Rab17 belongs to the Rab family of small Ras-like GTPases. It is specifically expressed in epithelial cells and is upregulated during cell polarization. Immunofluorescence staining studies indicate that Rab17 is associated with the perinuclear recycling endosome in nonpolarized epithelial cells and with the apical recycling endosome in polarized epithelial cells. The function of Rab17 remains unclear. Reports of Rab17 colocalization with internalized IgA in the apical endosome suggest that it may regulate receptor-mediated transcytosis. Rab17 has also been shown to regulate melanocytic filopodia formation and melanosome trafficking. siRNA knockdown of Rab17 in melanoma cells induces melanosome accumulation in the cell periphery.