SNIP1 antibody (AA 301-396) (HRP)

Catalog No. ABIN1408112

The Rabbit Polyclonal anti-SNIP1 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect SNIP1 in samples from Human.

Quick Overview for SNIP1 antibody (AA 301-396) (HRP) (ABIN1408112)

Target: SNIP1 (Smad Nuclear Interacting Protein 1 (SNIP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNIP1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SNIP1 Antibody (HRP)

Binding Specificity: AA 301-396

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SNIP1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SNIP1

Target: SNIP1 (Smad Nuclear Interacting Protein 1 (SNIP1))

Alternative Name: SNIP1

Background:

Synonyms: FHA domain-containing protein SNIP1, FLJ12553, Smad nuclear interacting protein Smad nuclear interacting, Smad nuclear interacting protein, Smad nuclear-interacting protein 1, SNIP1 Smad nuclear interacting protein, SNIP1, SNIP1_HUMAN, Splicing factor arginine/serine rich 4 Pre mRNA splicing factor SRP75.

Background: Members of the transforming growth factor-beta (TGF-Beta) superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-Beta family ligands are mediated by Smad proteins. The Smad nuclear interacting protein (SNIP1) contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 potently inhibits the activity of NF-kappa B, which binds the C/H1 domain of CBP/p300, by competing for the binding site. SNIP1 is also thought to induce expression of Cyclin D1 to promote cellular proliferation. SNIP1 is ubiquitously expressed with high expression in heart and skeletal muscle.

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection