Calsyntenin 2 antibody (AA 261-360) (HRP)

Catalog No. ABIN1408580

The Rabbit Polyclonal anti-Calsyntenin 2 antibody is suitable to detect Calsyntenin 2 in samples from Human. It has been validated for IHC (fro) and IHC (p).

Quick Overview for Calsyntenin 2 antibody (AA 261-360) (HRP) (ABIN1408580)

Target: Calsyntenin 2 (CLSTN2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calsyntenin 2 antibody is conjugated to HRP

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Calsyntenin 2 Antibody (HRP)

Binding Specificity: AA 261-360

Purpose: CLSTN2 Polyclonal Antibody, HRP Conjugated

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLSTN2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Calsyntenin 2

Target: Calsyntenin 2 (CLSTN2)

Alternative Name: CLSTN2

Background:

Synonyms: Alc, Alcadein, Alcadein Gamma, Alcagamma, Alzheimer's disease related cadherin like protein, Calsyntenin 2, CLSTN 2, CS 2, CS2, FLJ39113, FLJ39499, MGC119560, CSTN2_HUMAN.

Background: Members of the calsyntenin protein family are localized to the post-synaptic membrane of exicitatory central nervous system (CNS) synapses. Calsyntenin-2, also known as Alcadein-gamma, is a 955 amino acid protein that localizes to the endoplasmic reticulum, golgi apparatus and plasma membranes. Containing 2 cadherin-like repeats in its N-terminal extracellular region, calsyntenin-2 binds synaptic calcium with its cytoplasmic domain, suggesting a role in the modulation of calcium-mediated postsynaptic signals. Under normal physiological conditions, calsyntenin-2 is protoeolytically processed in an event in which the primary zeta-cleavage generates a short C-terminal transmembrane fragment and a long extracellular N-terminal domain.