NMUR2 antibody (AA 181-230) (HRP)

Catalog No. ABIN1409072

The Rabbit Polyclonal anti-NMUR2 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect NMUR2 in samples from Human.

Quick Overview for NMUR2 antibody (AA 181-230) (HRP) (ABIN1409072)

Target: NMUR2 (Neuromedin U Receptor 2 (NMUR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMUR2 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-NMUR2 Antibody (HRP)

Binding Specificity: AA 181-230

Predicted Reactivity: Human,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NMUR2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NMUR2

Target: NMUR2 (Neuromedin U Receptor 2 (NMUR2))

Alternative Name: NMUR2/GPR-FM4

Background:

Synonyms: FM4, G protein coupled receptor FM 4, G protein coupled receptor TGR 1, G-protein coupled receptor FM-4, G-protein coupled receptor TGR-1, Neuromedin U receptor 2, Neuromedin-U receptor 2, NMU R2, NMU-R2, NMU2R, NMUR2, NMUR2_HUMAN, TGR1

Background: Neuromedin U is a neuropeptide with high activity on smooth muscle. It is widely expressed in gastrointestinal systems and central nervous system (CNS). Peripheral activities of neuromedin U include smooth muscle stimulation, ion transport alterations in the gut and the regulation of local blood flow and adrenocortical function. Neuromedin U receptors 1 and 2 (NMUR1 and NMUR2) are multi-pass membrane proteins that belong to the G-protein coupled receptor 1 family of proteins. Both NMUR1 and NMUR2 act as receptors for the neuromedin U neuropeptide. NMUR1 is detected in peripheral organs, particularly in urogenital and gastrointestinal systems, with highest levels in testis. It?s expression in CNS is low, but the protein has been detected in cerebellum, hippocampus, dorsal root ganglia and spinal cord. NMUR2 is predominantly detected in central nervous system with highest levels detected in medulla oblongata, spinal cord and thalamus. It may also be detected in testis but has low levels of expression in peripheral tissues.

Gene ID: 56923

UniProt: Q9GZQ4

Pathways: Feeding Behaviour