UNC5D antibody (AA 112-200) (Cy3)

Catalog No. ABIN1409487

This anti-UNC5D antibody is a Rabbit Polyclonal antibody detecting UNC5D in WB, IF (cc), IF (p). Suitable for Human.

Quick Overview for UNC5D antibody (AA 112-200) (Cy3) (ABIN1409487)

Target: UNC5D (Unc-5 Homolog D (UNC5D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC5D antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-UNC5D Antibody (Cy3)

Binding Specificity: AA 112-200

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UNC5H4

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for UNC5D

Target: UNC5D (Unc-5 Homolog D (UNC5D))

Alternative Name: UNC5D/UNC5H4

Background:

Synonyms: Netrin receptor UNC5D, Netrin receptor Unc5h4, Protein unc 5 homolog D, Unc 5 homolog 4, Unc 5 homolog D C. elegans, Unc 5 homolog D, UNC 5D, Unc5h4, FLJ16019, KIAA1777.

Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.