UNC5D antibody (AA 160-240)

Catalog No. ABIN7232044

This Rabbit Polyclonal antibody specifically detects UNC5D in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for UNC5D antibody (AA 160-240) (ABIN7232044)

Target: UNC5D (Unc-5 Homolog D (UNC5D))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC5D antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-UNC5D Antibody

Binding Specificity: AA 160-240

Purpose: Rabbit Anti-UNC5D Polyclonal Antibody

Specificity: The antibody detects endogenous levels of UNC5D protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human UNC5D protein at AA range: 160-240

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for UNC5D

Target: UNC5D (Unc-5 Homolog D (UNC5D))

Alternative Name: UNC5D

Background: Netrin receptor UNC5D, Protein unc-5 homolog 4, Protein unc-5 homolog DReceptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed: 24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell.

Molecular Weight: 104kD

Gene ID: 137970

UniProt: Q6UXZ4