ENTPD2 antibody (AA 401-495) (HRP)

Catalog No. ABIN1409618

The Rabbit Polyclonal anti-ENTPD2 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect ENTPD2 in samples from Rat.

Quick Overview for ENTPD2 antibody (AA 401-495) (HRP) (ABIN1409618)

Target: ENTPD2 (Ectonucleoside Triphosphate diphosphohydrolase 2 (ENTPD2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ENTPD2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ENTPD2 Antibody (HRP)

Binding Specificity: AA 401-495

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Sheep,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ENTPD2/CD39L1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ENTPD2

Target: ENTPD2 (Ectonucleoside Triphosphate diphosphohydrolase 2 (ENTPD2))

Alternative Name: ENTPD2/CD39L1

Background:

Synonyms: CD39 antigen like 1, CD39 antigen-like 1, CD39 like1, CD39L1, CD39like1, ecto ATP diphosphohydrolase 2, ecto ATPase 2, ecto ATPDase 2, Ecto-ATP diphosphohydrolase 2, Ecto-ATPase 2, Ecto-ATPDase 2, ectoATPase 2, ectoATPDase 2, Ectonucleoside triphosphate diphosphohydrolase 2, ENTP2_HUMAN, Entpd2, NTPDase 2, NTPDase2.

Background: CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENP1), is an integral membrane glycoprotein that acts as an extracellular nucleotide-hydrolyzing enzyme. CD39 inhibits ADP-induced platelet aggregation by hydrolyzing ADP to AMP and ultimately generating adenosine. Intracellular CD39 undergoes glycosylation at 6 N-glycosylation sites and translocates to the membrane in order to be an active enzyme. CD39L1 is a 495 amino acid multi-pass membrane protein that requires calcium and magnesium cofactors to hydrolyze ATP and other nucleotides in the regulation of purigenic neurotransmission. CD39L1 is expressed in kidney, colon, heart, testis, pancreas, brain, prostate, skeletal muscle, small intestine and ovaries. There are two isoforms of CD39L1 that are produced as a result of alternative splicing events.