Glutamate Receptor 1 antibody (pSer863) (HRP)

Catalog No. ABIN1410320

The Rabbit Polyclonal anti-Glutamate Receptor 1 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect Glutamate Receptor 1 in samples from Human, Rat and Mouse.

Quick Overview for Glutamate Receptor 1 antibody (pSer863) (HRP) (ABIN1410320)

Target: Glutamate Receptor 1 (GLUR1)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutamate Receptor 1 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Glutamate Receptor 1 Antibody (HRP)

Binding Specificity: pSer863

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human GluR1 around the phosphorylation site of Ser863

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Glutamate Receptor 1

Target: Glutamate Receptor 1 (GLUR1)

Alternative Name: GluR1

Background:

Synonyms: p-GluR-1Ser 863, p-GluR1Ser863, Glutamate Receptor 1 phospho S863, Glutamate Receptor 1 phospho Ser863, GLUR 1, GLUR A, AMPA 1, GluR-1, AMPA selective glutamate receptor 1, AMPA-selective glutamate receptor 1, GluA1, GLUH 1, GLUH1, GluR K1, GluR-1, GluR-A, GluR-K1, GLUR1, GLURA, GluRK1, Glutamate receptor 1, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic, Glutamate receptor, ionotropic, AMPA 1, Gria 1, Gria1, GRIA1_HUMAN, HBGR1, MGC133252, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243.

Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Pathways: PI3K-Akt Signaling