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Ataxin 10 antibody (AA 21-120) (HRP)

The Rabbit Polyclonal anti-Ataxin 10 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect Ataxin 10 in samples from Mouse and Rat.
Catalog No. ABIN1411328

Quick Overview for Ataxin 10 antibody (AA 21-120) (HRP) (ABIN1411328)

Target

See all Ataxin 10 (ATXN10) Antibodies
Ataxin 10 (ATXN10)

Reactivity

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  • 3
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  • 2
  • 2
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Mouse, Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This Ataxin 10 antibody is conjugated to HRP

Application

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

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    AA 21-120

    Cross-Reactivity

    Mouse, Rat

    Predicted Reactivity

    Human,Dog,Cow,Sheep,Pig,Horse

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human ATXN10/SCA10

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handling Advice

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    Ataxin 10 (ATXN10)

    Alternative Name

    ATXN10/SCA10

    Background

    Synonyms: Ataxin 10, Ataxin-10, ATX10_HUMAN, Atxn10, Brain protein E46 homolog, E46L, FLJ37990, HUMEEP, Like mouse brain protein E46, SCA10, Spinocerebellar ataxia 10, Spinocerebellar ataxia type 10 protein.

    Background: Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.

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