CSDC2 antibody (AA 21-120) (Cy3)

Catalog No. ABIN1411425

The Cy3-conjugated Rabbit Polyclonal anti-CSDC2 antibody (ABIN1411425) specifically detects CSDC2 in WB, IF (cc) and IF (p). The antibody is reactive with Human samples.

Quick Overview for CSDC2 antibody (AA 21-120) (Cy3) (ABIN1411425)

Target: CSDC2 (Cold Shock Domain Containing C2, RNA Binding (CSDC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSDC2 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CSDC2 Antibody (Cy3)

Binding Specificity: AA 21-120

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PIPPIN

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CSDC2

Target: CSDC2 (Cold Shock Domain Containing C2, RNA Binding (CSDC2))

Alternative Name: CSDC2/PIPPIN

Background:

Synonyms: Cold shock domain containing C2 RNA binding, Cold shock domain containing protein C2, Cold shock domain-containing protein C2, CSDC 2, Csdc2, CSDC2_HUMAN, dJ347H13.2, PIPPIN, RNA binding protein PIPPin, RNA-binding protein PIPPin.

Background: PIPPIN is a Y-box protein (also called cold-shock (CSD) domain-containing protein) and belongs to a family of highly conserved RNA-binding transcriptional regulators. Predominantly expressed in brain cells and localizing to the nucleus and the cytoplasm, PIPPIN contains two RNA-binding motifs, namely PIP1 and PIP2, and one CSD domain. PIPPIN functions as a nucleic acid binding regulatory factor and is believed to participate in brain maturation. More specifically, PIPPIN binds to the 3?-UTR ends of the mRNAs encoding Histone H1 and Histone H3.3. This interaction requires all of the PIPPIN domains to work in concert as one functional protein. In addition, PIPPIN can be sumoylated in a thyroid hormone (T3)-dependent manner. This suggests that PIPPIN modification in response to extracellular stimuli may modulate the regulation of protein synthesis.