KIAA0319 antibody (AA 682-760) (Cy3)

Catalog No. ABIN1411653

This anti-KIAA0319 antibody is a Rabbit Polyclonal antibody detecting KIAA0319 in WB, IF (cc) and IF (p). Suitable for Human.

Quick Overview for KIAA0319 antibody (AA 682-760) (Cy3) (ABIN1411653)

Target: KIAA0319

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIAA0319 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-KIAA0319 Antibody (Cy3)

Binding Specificity: AA 682-760

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DYX2/KIAA0319

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KIAA0319

Target: KIAA0319

Alternative Name: DYX2/KIAA0319

Background:

Synonyms: DLX 2, DLX2, DYLX 2, DYLX2, Dyslexia susceptibility 2, Dyslexia-associated protein KIAA0319 DYX 2, DYX2, K0319_HUMAN, Kiaa0319, MGC176717.

Background: DYX2 is a 1072 amino acid single-pass transmembrane protein that contains one MANSC domain and two PKD (Polycystic Kidney Disease) domains, which are usually found in the extracellular regions of proteins and are involved in protein-protein interactions. In DYX2, it is likely that its PKD domains mediate the interaction between neurons and glial fibers during neuronal migration. When overexpressed, this plasma membrane protein colocalizes with EEA1 (early endosome antigen 1) in large intracellular vesicles, suggesting that it is endocytosed and recycled. DYX2 is highly expressed in brain cortex, cerebellum, amygdala, putamen and hippocampus. Defects in the gene encoding DYX2 may be the cause of dyslexia type 2, a relatively common disorder that is characterized by reading performance impairment in the absence of sensory or neurologic disability. There are three isoforms of DYX2 that are produced as a result of alternative splicing events