PPP2R5D antibody (AA 501-602) (Cy3)

Catalog No. ABIN1412415

The Cy3-conjugated Rabbit Polyclonal anti-PPP2R5D antibody (ABIN1412415) specifically detects PPP2R5D in WB, IF (cc) and IF (p). The antibody is reactive with Mouse and Rat samples.

Quick Overview for PPP2R5D antibody (AA 501-602) (Cy3) (ABIN1412415)

Target: PPP2R5D (Protein Phosphatase 2, Regulatory Subunit B', delta (PPP2R5D))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2R5D antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-PPP2R5D Antibody (Cy3)

Binding Specificity: AA 501-602

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PPP2R5D

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PPP2R5D

Target: PPP2R5D (Protein Phosphatase 2, Regulatory Subunit B', delta (PPP2R5D))

Alternative Name: PPP2R5D

Background:

Synonyms: B'delta, Delta isoform of regulatory subunit B56, protein phosphatase 2A, MGC2134, MGC8949, OTTHUMP00000039821, PP2A B subunit B' delta isoform, PP2A B subunit B56 delta isoform, PP2A B subunit PR61 delta isoform, PP2A B subunit R5 delta isoform, Protein phosphatase 2 regulatory subunit B B56 delta isoform, Protein phosphatase 2 regulatory subunit B delta isoform, Serine threonine protein phosphatase 2A 56 kDa regulatory subunit delta isoform, TEG-271, Tex271, 2A5D_HUMAN.

Background: In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2A Alpha and PP2A Beta. The PP2A catalytic subunit associates with a variety of regulatory subunits. Regulatory subunits include PP2A-A-Alpha and -A-Beta, PP2A-B-Alpha and -B-Beta, PP2A-C-Alpha and -C-Beta, PP2A-B56-Alpha, -B56-Beta, -B56-gamma and -B56-Delta.

Pathways: PI3K-Akt Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades