DLGAP4 antibody (AA 261-370) (HRP)

Catalog No. ABIN1413290

Product Details anti-DLGAP4 Antibody (HRP)

Target: DLGAP4 (Discs, Large (Drosophila) Homolog-Associated Protein 4 (DLGAP4))

Binding Specificity: AA 261-370

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLGAP4 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SAPAP4/DLGAP4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DLGAP4

Target: DLGAP4 (Discs, Large (Drosophila) Homolog-Associated Protein 4 (DLGAP4))

Alternative Name: SAPAP4/DLGAP4 (DLGAP4 Products)

Synonyms: DAP4 antibody, DLP4 antibody, RP5-977B1.6 antibody, SAPAP4 antibody, MGC155295 antibody, DKFZp469I1627 antibody, AI225853 antibody, BC024558 antibody, DAP-4 antibody, SAPAP-4 antibody, Sapap4 antibody, WBP16 antibody, Dap4 antibody, DLG associated protein 4 antibody, discs, large (Drosophila) homolog-associated protein 4 antibody, discs, large homolog-associated protein 4 (Drosophila) antibody, DLGAP4 antibody, dlgap4 antibody, Dlgap4 antibody

Background:

Synonyms: DAP 4, DAP-4, DAP4, Discs, large Drosophila homolog associated protein 4, Disks large associated protein 4, Disks large-associated protein 4, DLGAP4, DLGP4_HUMAN, DLP4, PSD 95/SAP90 binding protein 4, PSD-95/SAP90-binding protein 4, RP5-977B1.6, SAP90/PSD-95-associated protein 4, SAPAP 4, SAPAP-4, SAPAP4.

Background: A guanylate kinase is a phosphotransferase that produces ADP and GDP from the substrates ATP and GMP. SAPAP4 is a 992 amino acid protein that likely localizes to the postsynaptic membrane of neurons to enhance neuronal signaling. SAPAP4 could act as a signaling molecule which interacts with the human genes DLG1 and DLG4/PSD-95. The gene encoding SAPAP4, DLGAP4, maps to human chromosome 20. Comprising approximately 2 % of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.