FAS antibody (AA 81-170) (Cy5)
Quick Overview for FAS antibody (AA 81-170) (Cy5) (ABIN1415387)
Target
See all FAS AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 81-170
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Cross-Reactivity
- Human, Mouse, Rat
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Predicted Reactivity
- Pig
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Purification
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human FAS/Apo-1
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Isotype
- IgG
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Application Notes
- FCM 1:20-100
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Expiry Date
- 12 months
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- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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Alternative Name
- Apo-1
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Background
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Synonyms: APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6, Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, FAS
Background: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
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Gene ID
- 355
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UniProt
- P25445
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Pathways
- p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
Target
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