DYDC1 antibody (AA 101-177) (Cy3)

Catalog No. ABIN1416083

The Rabbit Polyclonal anti-DYDC1 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect DYDC1 in samples from Human.

Quick Overview for DYDC1 antibody (AA 101-177) (Cy3) (ABIN1416083)

Target: DYDC1 (DPY30 Domain Containing 1 (DYDC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYDC1 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-DYDC1 Antibody (Cy3)

Binding Specificity: AA 101-177

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DYDC1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DYDC1

Target: DYDC1 (DPY30 Domain Containing 1 (DYDC1))

Alternative Name: DYDC1

Background:

Synonyms: DPY30 domain-containing protein 1, DPY30D1, DYDC1, DYDC1_HUMAN, RSD 9, RSD9.

Background: The Dumpy-30 (DPY-30) protein was first described in C. elegans, in which it is involved in dosage compensation of sex chromosomes. Conserved from yeast to humans, the DPY-30 family is involved in gene expression and chromatin modification, specifically histone methylation. DPY-30 and closely related proteins contain a short motif that is related to the dimerization motif in the regulatory subunit of protein kinase A (PKA), which consists of two ?helices that form a four-helix bundle during dimerization. As a member of the DPY-30 family, DYDC1 (DPY30 domain-containing protein 1), also known as DPY30D1 and RSD9, is a 177 amino acid protein that binds to Endophilin III and plays a crucial role during acrosome biogenesis. DYDC1 is specifically expressed in brain and testis and accumulates in the acrosome area during spermatogenesis. Knockdown of DYDC1 mRNA results in disruption of acrosome formation and spermatid differentiation.

Gene ID: 143241