ELL3 antibody (AA 51-158) (Cy3)

Catalog No. ABIN1417595

The Rabbit Polyclonal anti-ELL3 antibody is suitable to detect ELL3 in samples from Human. It has been validated for IF (cc) and IF (p).

Quick Overview for ELL3 antibody (AA 51-158) (Cy3) (ABIN1417595)

Target: ELL3 (Elongation Factor RNA Polymerase II-Like 3 (ELL3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELL3 antibody is conjugated to Cy3

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ELL3 Antibody (Cy3)

Binding Specificity: AA 51-158

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ELL3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ELL3

Target: ELL3 (Elongation Factor RNA Polymerase II-Like 3 (ELL3))

Alternative Name: ELL3

Background:

Synonyms: B cell translocation gene 2, BTG family member 2, Btg2, BTG2_HUMAN, Nerve growth factor inducible anti prolerative, NGF inducible anti prolerative protein PC3, NGF-inducible anti-prolerative protein PC3, PC3, Pheochromacytoma cell 3, Protein BTG2, TIS21.

Background: Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein), also designated MEN, functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. It is also thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, with lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. ELL3 is a 397 amino acid nuclear protein that functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Though similar to ELL and ELL2, ELL3 is exclusively expressed in testis.

Gene ID: 80237

Pathways: Negative Regulation of intrinsic apoptotic Signaling