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MARCH9 antibody (HRP)

MARCH9 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal HRP
Catalog No. ABIN1420048
  • Target See all MARCH9 Antibodies
    MARCH9 (Membrane-Associated Ring Finger (C3HC4) 9 (MARCH9))
    Reactivity
    • 41
    • 24
    • 21
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 38
    • 2
    Rabbit
    Clonality
    • 39
    • 2
    Polyclonal
    Conjugate
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MARCH9 antibody is conjugated to HRP
    Application
    • 40
    • 16
    • 13
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MARCH9
    Isotype
    IgG
    Top Product
    Discover our top product MARCH9 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    MARCH9 (Membrane-Associated Ring Finger (C3HC4) 9 (MARCH9))
    Alternative Name
    MARCH9 (MARCH9 Products)
    Synonyms
    Rnf179 antibody, March-IX antibody, MARCH-IX antibody, RNF179 antibody, AI608492 antibody, BC019560 antibody, membrane associated ring-CH-type finger 9 antibody, membrane associated ring-CH-type finger 9 S homeolog antibody, membrane-associated ring finger (C3HC4) 9 antibody, March9 antibody, march9.S antibody, MARCH9 antibody, march9 antibody
    Background

    Synonyms: E3 ubiquitin protein ligase MARCH9, MARCH IX, Membrane associated RING CH protein IX, membrane associated ring finger C3HC4 9, Membrane associated RING finger protein 9, RING finger protein 179, RNF179, MARH9_HUMAN.

    Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH9 (membrane-associated ring finger (C3HC4) 9), also known as RNF179, is a 346 amino acid multi-pass membrane protein that localizes to the golgi apparatus and contains one RING-CH-type zinc finger. Expressed ubiquitously, MARCH9 exists as a homodimer and functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to promote the degradation of target proteins, such as CD4 and MHC-I. Multiple isoforms of MARCH9 exist due to alternative splicing events.

    Gene ID
    92979
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