CCDC180 antibody (HRP)

Catalog No. ABIN1420894

Product Details anti-CCDC180 Antibody (HRP)

Target: CCDC180 (Coiled-Coil Domain Containing 180 (CCDC180))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC180 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C9orf174

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CCDC180

Target: CCDC180 (Coiled-Coil Domain Containing 180 (CCDC180))

Alternative Name: C9orf174 (CCDC180 Products)

Synonyms: BDAG1 antibody, C9orf174 antibody, KIAA1529 antibody, coiled-coil domain containing 180 antibody, CCDC180 antibody

Background:

Synonyms: BDAG1, Behcet's Disease Associated Gene 1, C9orf174, DKFZp434I2420, DKFZp686B2031, DKFZp686G1725, FLJ41397, FLJ50036, Hypothetical protein LOC100499483, KIAA1529, Uncharacterized protein C9orf174, CI174_HUMAN.

Background: Chromosome 9 consists of about 145 million bases and 4 % of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The KIAA1529 gene product has been provisionally designated KIAA1529 pending further characterization.