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MIS18 Binding Protein 1 (MIS18BP1) antibody (Cy5)

This anti- antibody is a Rabbit Polyclonal antibody detecting in WB and IF (p). Suitable for Human, Mouse and Rat.
Catalog No. ABIN1421532

Quick Overview for MIS18 Binding Protein 1 (MIS18BP1) antibody (Cy5) (ABIN1421532)

Target

See all MIS18 Binding Protein 1 (MIS18BP1) Antibodies
MIS18 Binding Protein 1 (MIS18BP1)

Reactivity

  • 18
  • 14
  • 14
  • 1
Human, Mouse, Rat

Host

  • 16
  • 2
Rabbit

Clonality

  • 18
Polyclonal

Conjugate

  • 5
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Cy5

Application

  • 18
  • 12
  • 3
  • 2
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Cross-Reactivity

    Human, Mouse, Rat

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human KNL2/C14orf106

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    MIS18 Binding Protein 1 (MIS18BP1)

    Alternative Name

    C14orf106

    Background

    Synonyms: Chromosome 14 open reading frame 106, HsKNL-2, KIAA1903, Kinetochore-associated protein KNL-2 homolog, M18BP1, Mis18-binding protein 1, MIS18BP1, P243, Putative protein p243 which interacts with transcription factor Sp1, Uncharacterized potential DNA binding protein C14orf106, M18BP_HUMAN.

    Background: C14orf106 is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It interacts with SP1. There are two isoforms.Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5 % of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14,19) translocations found in a variety of B cell malignancies. The C14orf106 gene product has been provisionally designated C14orf106 pending further characterization.

    Pathways

    Chromatin Binding
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