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CLNS1A antibody (HRP)

This Rabbit Polyclonal antibody specifically detects CLNS1A in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.
Catalog No. ABIN1422904

Quick Overview for CLNS1A antibody (HRP) (ABIN1422904)

Target

See all CLNS1A Antibodies
CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))

Reactivity

  • 42
  • 20
  • 18
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Mouse, Rat

Host

  • 39
  • 3
Rabbit

Clonality

  • 39
  • 3
Polyclonal

Conjugate

  • 23
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CLNS1A antibody is conjugated to HRP

Application

  • 35
  • 13
  • 6
  • 6
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Cross-Reactivity

    Human, Mouse, Rat

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human CLNS1A/pICln

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handling Advice

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))

    Alternative Name

    CLNS1A

    Background

    Synonyms: nucleotide sensitive 1A, Chloride channel, Chloride channel nucleotide sensitive 1A, Chloride channel regulatory protein, Chloride conductance regulatory protein ICln, Chloride ion current inducer protein, ClCI, CLNS 1A, Clns1a, CLNS1B, ICln, ICln, ICLN_HUMAN, Methylosome subunit pICln, Reticulocyte pICln

    Background: The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron (SMN) protein, and is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 (also designated Jak-binding protein 1, JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG) domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved, ubiquitously expressed protein that localizes primarily to the cytoplasm, and may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1.

    Gene ID

    1207

    Pathways

    Ribonucleoprotein Complex Subunit Organization
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