LRRTM3 antibody (AA 31-120) (PE)

Catalog No. ABIN1427140

This Rabbit Polyclonal antibody specifically detects LRRTM3 in WB and FACS. It exhibits reactivity toward Human.

Quick Overview for LRRTM3 antibody (AA 31-120) (PE) (ABIN1427140)

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRTM3 antibody is conjugated to PE

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-LRRTM3 Antibody (PE)

Binding Specificity: AA 31-120

Purpose: LRRTM3 Polyclonal Antibody, PE Conjugated

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Sheep,Pig,Chicken,Rabbit,Monkey

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LRRTM3

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), FCM(1:20-100)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LRRTM3

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Alternative Name: LRRTM3

Background:

Synonyms: Leucine rich repeat transmembrane neuronal protein 3, Leucine-rich repeat transmembrane neuronal protein 3, LRRT3_HUMAN, Lrrtm3, MGC131810, PRO1693, UNQ803.

Background: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM3 (leucine rich repeat transmembrane neuronal 3) is a 581 amino acid single-pass type I membrane protein belonging to the LRRTM family. LRRTM3 is involved in the development and maintenance of the vertebrate nervous system, and contains ten LRR repeats. Expressed in neuronal tissues, LRRTM3 is encoded by a gene that maps to a region of chromosome 10 that has been linked to late-onset Alzheimer disease and elevated plasma Beta-Amyloid. As a result of alternative splicing events, two LRRTM3 isoforms exist.

Pathways: Synaptic Membrane