GABRG3 antibody (PE)

Catalog No. ABIN1429625

The Rabbit Polyclonal anti-GABRG3 antibody is suitable to detect GABRG3 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for GABRG3 antibody (PE) (ABIN1429625)

Target: GABRG3 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 3 (GABRG3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRG3 antibody is conjugated to PE

Application: Western Blotting (WB)

Product Details anti-GABRG3 Antibody (PE)

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GABRG3/GABA A Receptor gamma 3

Isotype: IgG

Application Details

Application Notes: FCM(1:20-100)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GABRG3

Target: GABRG3 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 3 (GABRG3))

Alternative Name: Gabrg3/Gaba A Receptor gamma 3

Background:

Synonyms: GABAA receptor, GABAA receptor subunit gamma 3, GABR G3, GABRG 3, GABRG3, Gamma aminobutyric acid GABA A receptor gamma 3, Gamma aminobutyric acid A receptor gamma 3, Gamma aminobutyric acid receptor subunit gamma 3, GBRG3_HUMAN.

Background: GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R Alpha 1-6, GABAA R Beta 1-3, GABAA R Gamma 1-3, GABAA R Delta, GABAA R Epsilon, GABAA R Zeta 1 and GABAA R Zeta 2. The GABAB family is composed of GABAB R1 Alpha and GABAB R1 Beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.