GABRQ antibody (PE)

Catalog No. ABIN1429640

The Rabbit Polyclonal anti-GABRQ antibody is suitable to detect GABRQ in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for GABRQ antibody (PE) (ABIN1429640)

Target: GABRQ (gamma-aminobutyric Acid (GABA) Receptor, theta (GABRQ))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRQ antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-GABRQ Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GABRQ/GABA A Receptor ta

Isotype: IgG

Application Details

Application Notes: FCM(1:20-100)

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details for GABRQ

Target: GABRQ (gamma-aminobutyric Acid (GABA) Receptor, theta (GABRQ))

Alternative Name: Gabrq/Gaba A Receptor theta

Background:

Gamma-aminobutyric acid type A (GABAA) receptors mediate inhibitory neurotransmission in the mammalian central nervous system. The receptor exists as a pentameric ion channel composed by heteromeric combinations of alpha, beta, gamma, delta, epsilon, theta, or pi subunits. Only specific subunit combinations produce viable receptors, while others never translocate to the cell surface from the ER where they are synthesized, and subsequently degraded. The theta subunit forms a receptor in combination with alpha3 subunits in monoaminergic cell groups. These receptors, found especially in the septum, preoptic areas, hypothalamic nuclei, amygdala and thalamus, likely have unique pharmacological properties linked to their expression in this particular cell type and not cholinergic cell groups, and may play a role in opiate withdrawl symptoms.

Subcellular location: Extracellular

Synonyms: gamma aminobutyric acid GABA receptor, theta, Gamma aminobutyric acid receptor theta subunit precursor, gamma aminobutyric acid receptor, theta, THETA, GBRT_HUMAN.