GABRQ antibody (N-Term)

Catalog No. ABIN2776224

Cited in 1 publication. The Rabbit Polyclonal anti-GABRQ antibody (ABIN2776224) specifically detects GABRQ in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse and Pig samples.

Quick Overview for GABRQ antibody (N-Term) (ABIN2776224)

Target: GABRQ (gamma-aminobutyric Acid (GABA) Receptor, theta (GABRQ))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRQ antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GABRQ Antibody

Binding Specificity: N-Term

Purpose: GABRQ Antibody - N-terminal region

Sequence: KFHFEFSSAV PEVVLNLFNC KNCANEAVVQ KILDRVLSRY DVRLRPNFGG

Predicted Reactivity: Cow: 87%, Dog: 87%, Guinea Pig: 80%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GABRQ. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GABRQ

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101293

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-GABRQ antibody (ABIN2776224)

Fatemi, Folsom, Rooney, Thuras: "mRNA and protein expression for novel GABAA receptors ? and ?2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway." in: Translational psychiatry, Vol. 3, pp. e271, (2013) (PubMed).

Target Details for GABRQ

Target: GABRQ (gamma-aminobutyric Acid (GABA) Receptor, theta (GABRQ))

Alternative Name: GABRQ

Background:

Targeted Subunit: theta

Background Information: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, theta subunit. GABRQ gene is mapped to chromosome Xq28 in a cluster including the genes encoding the alpha 3 and epsilon subunits of the same receptor. This gene location is also the candidate region of 2 different neurologic diseases:early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3).The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, theta subunit. It is mapped to chromosome Xq28 in a cluster including the genes encoding the alpha 3 and epsilon subunits of the same receptor. This gene location is also the candidate region of 2 different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3).

Gene Name: Gamma-aminobutyric acid (GABA) A receptor, theta

Alternative Symbols: THETA

Protein Name: Gamma-aminobutyric acid receptor subunit theta

Molecular Weight: 72kDa

Gene ID: 55879

NCBI Accession: NP_061028

UniProt: Q9UN88