KCNF1 antibody (PE)

Catalog No. ABIN1430075

The Rabbit Polyclonal anti-KCNF1 antibody is suitable to detect KCNF1 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for KCNF1 antibody (PE) (ABIN1430075)

Target: KCNF1 (Potassium Voltage-Gated Channel, Subfamily F, Member 1 (KCNF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNF1 antibody is conjugated to PE

Application: Western Blotting (WB)

Product Details anti-KCNF1 Antibody (PE)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KCNF1

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KCNF1

Target: KCNF1 (Potassium Voltage-Gated Channel, Subfamily F, Member 1 (KCNF1))

Alternative Name: Kcnf1

Background:

Synonyms: IK 8, IK8, KCNF 1, KCNF, Kcnf1, KCNF1_HUMAN, kH 1, kH1, KV5.1, Potassium voltage-gated channel subfamily F member 1, MGC33316, Potassium channel KH1, Potassium channel Kv5.1, Potassium voltage gated channel subfamily F member 1, Potassium voltage-gated channel subfamily F member 1, Voltage gated potassium channel subunit Kv5.1, Voltage-gated potassium channel subunit Kv5.1.

Background: KCNF1 is a multi-pass membrane-bound protein that acts as an ion channel and is generally expressed as a heterotetramer of potassium channeling proteins. Formerly known as kH1, KCNF1 is usually found as a heteromer with three other potassium channel proteins, KCNG3, KV6.3 and KCNV2. As a potassium channel protein, KCNF1 plays a role in regulating apoptosis and proliferation of pulmonary artery smooth muscle (PASM) cells. Bone morphogenetic proteins (BMPs) restrict proliferation and can induce apoptosis in normal human PASM cells and will upregulate expression of KCNF1 in PASM cells in vitro. KCNF1 is expressed in heart, brain, liver, skeletal muscle, kidney and pancreas.